BONES, JOINT &
INFLAMMATION
Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization.
Vitamin D plays an important role in bone health, heart health and immune support while working with vitamin K to support normal absorption of calcium and promote healthy arteries.
Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.Vitamin K is included in Isotonix Vitamin D with K2 because of its unique partnership
with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.At
least two naturally occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are
distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure, which results in different pharmacokinetic properties. Vitamin K1
is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications. Vitamin K2 has a different mechanism of action. It is
transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.   Some studies have
concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to
take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

Benefits:

The first supplement of its kind to combine vitamin D with vitamin K2 in an isotonic form!!!
These two superstar nutrients are linked to many health benefits!
An estimated 40%-75% of people are deficient in vitamin D!
Supports vascular health & calcium utilization
Promotes normal bone mineral density
Promotes healthy arteries
Supports immune health
Additional Benefits -
Essential for calcium absorption and utilization
Promotes healthy bone composition
Promotes teeth, bone and muscle health
Helps maintain bone mass by supporting normal osteoclast activity
Helps maintain cardiovascular health
Promotes elasticity of blood vessels
Helps maintain normal blood pressure
Women with low bone density have been found to be deficient in vitamin K
Together with calcium, vitamin D can help prevent osteoporosis in older individuals

INGREDIENTS:
Vitamin D3 (Cholecalciferol) (5000 IU)
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient
intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin
D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of
exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption, and reduced metabolism to active forms of vitamin D by the kidneys, all of
which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition
to promoting strong bones, vitamin D also has other roles in health, including supporting the body's normal modulation of neuromuscular function and immune function. Vitamin D has been
shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body's normal regulation of T-cell function. In reference to cellular
health, Vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated
to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood
pressure.*

Vitamin K2 (45 mcg)
Vitamin K is a fat-soluble vitamin found meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary
intake.Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy
food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K
to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often
referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls). These
events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a
post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These
carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of
proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While vitamin D supports the healthy regulation and synthesis of osteocalcin, the
mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found
throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a
cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*
VITAMIN D FOR BONES &
JOINTS WITH K1 & K2